Synevra UltraLift is a peptide serum built around SYN-AKE, hyaluronic acid and vitamins C and E, sold on its own or bundled with a skin-nutrient capsule the brand calls VitaLock. Sensible ingredients, honest wording, a 60-day refund. Not a facelift in a bottle, and it doesn't claim to be.
From $59/serum on the Lift & Lock bundle · Non-GMO · Paraben-Free · 60-day guarantee

The idea behind Synevra is that you treat skin from two directions. On the outside, a light serum with a wrinkle-relaxing peptide, hyaluronic acid and two antioxidant vitamins. On the inside, an optional capsule of the nutrients that keep coming up in dermatology research on skin, hair and nails. The brand calls the pairing "Lift & Lock" and describes it as Swiss-inspired, which mostly means the formulation philosophy rather than where it's made.
The serum's headline ingredient is SYN-AKE, a synthetic dipeptide that mimics a compound in temple viper venom and is meant to calm the tiny muscle movements that fold skin into lines. Behind it are sodium hyaluronate, vitamin C, vitamin E and glycerin, none of which need introducing. It's non-GMO, paraben-free, cruelty-free, made in an FDA-registered facility, and it comes with a 60-day refund. Everything on this page treats it as what it is: a cosmetic that changes how skin looks, not a medicine that changes what skin is.
| Point | Details |
|---|---|
| Product Name | Synevra UltraLift (focused peptide serum) — part of the Lift & Lock System |
| Category | Skin-firming & anti-aging beauty support |
| Main Support | Firmness, hydration, elasticity, and smoother-looking skin |
| Best For | Adults wanting daily skincare and youthful-appearance support |
| Form | Topical pump serum (0.5 oz / 15 ml) + optional VitaLock capsules |
| Key Ingredients | SYN-AKE peptide, sodium hyaluronate, vitamin C, vitamin E, glycerin |
| Pricing | $79 single serum; bundles from $59–$69 per serum |
| Qualities | Non-GMO, paraben-free, cruelty-free; FDA-registered facility |
| Refund Policy | 60-day "Love It or It's Free" money-back guarantee |

Most anti-aging products are one cream doing one thing. Synevra splits the job. The serum handles hydration, the look of lines and antioxidant protection on the surface; the VitaLock capsule handles the nutrients that skin builds itself from. Whether you need the second half depends on your diet, and we say so below.
In the serum, SYN-AKE goes after expression lines, the ones from smiling and squinting. Hyaluronic acid plumps with water so those lines look shallower. Vitamins C and E add brightness and some defense against daily oxidative wear. It's a well-worn combination, and that's a compliment: these are the ingredients with the research behind them.
Four things happen at once when you apply it. The peptide works on the look of expression lines, which form from repeated smiling, squinting and frowning. Hyaluronic acid pulls water into the upper skin so it looks fuller and lines look softer. Vitamin C and E brighten and protect. Glycerin holds the moisture in. None of it is dramatic on day one. Hydration you'll notice quickly; the rest takes weeks, and only works if you wear sunscreen, because there's no point protecting skin from oxidation in the morning and then burning it at lunch.
Used consistently, the system is presented as a way to support several visible outcomes:
These are appearance-level effects. They depend on using it consistently and they vary by skin. We'd rather say that plainly than have you expecting an injectable result from a serum.
Firmness and elasticity are what let your skin snap back after you smile or press it. They come from collagen and elastin in the dermis, and from how much water the skin is holding. From the mid-thirties on, collagen production slows, sun exposure breaks down what's there, and the skin holds less water. Lines appear where the skin used to spring back.
A serum can't put collagen back. What it can do is work the levers that change how skin looks: hydrate it so it looks plumper, protect it with antioxidants, and use peptides to soften the look of movement lines. That's what Synevra is built to do. For the biology behind firmness, our firmness guide goes deeper.
Five actives in the serum, five nutrients in the capsule. Here's what each is for.
The ingredient list name is Dipeptide Diaminobutyroyl Benzylamide Diacetate, which is why everyone calls it SYN-AKE. It's a synthetic copy of a small protein from viper venom that, in the lab, reduces the muscle contractions behind expression lines. In cosmetic studies it softened the look of forehead and eye lines over about a month. Topical, not injected, and nothing like the strength of a neurotoxin injection.
Hyaluronic acid in its stable salt form. It's a humectant that binds many times its weight in water, and it's the best-evidenced hydration ingredient in skincare. This is the ingredient you'll notice first: skin looks dewier within days.
The most-studied antioxidant in dermatology. Topical vitamin C brightens, evens tone, and is involved in the skin's own collagen-building process. Works best paired with vitamin E and worn under sunscreen.
The stable form of vitamin E. Mostly there to support the vitamin C and to help defend the skin barrier against daily oxidative wear. A supporting player, not a star.
Boring, cheap, and in nearly every good moisturizer for a reason. Draws water into the outer skin and keeps it there.
The VitaLock capsule adds biotin, niacinamide, vitamin B6, zinc and horsetail extract. These are the nutrients that keep appearing in dermatology reviews on skin, hair and nails, with the honest footnote that they help most when someone was short of them to begin with. If you eat well, the capsule is optional. The ingredients page links the research for each.
Every benefit below is about how skin looks, builds over weeks, and depends on using it every day. Results differ from person to person.
If you're not sure, put a little on your jawline for three days before using it on your face. If nothing happens, go ahead.
Follow the label. The routine is short:
Patch-test first, and read the leaflet in the box, which is more specific than we can be here.
The three below are typical of what users say. They're illustrative, not a statistic, and your skin won't behave exactly like anyone else's.

“I've had two people at work ask what I've changed. Nothing except this, morning and night, for about seven weeks. My skin looks less tired and the lines at the corners of my eyes are softer, not gone. It sinks in fast and doesn't fight with my sunscreen.”

“My dermatologist actually commented that my skin looked more hydrated at my last appointment, which she's never done. I like that it's two things: serum and a capsule with breakfast. I'd been doing a nine-step routine that I never finished.”

“I'm 61. I went into this expecting nothing and I'm now going out with tinted moisturizer instead of foundation, which for me is a big deal. My deeper forehead lines are still there. The general look of my skin is better.”
Three options on the official site, all one-time purchases with the 60-day refund. The bundles ship free and come with two guides. These were the prices when we last checked; confirm at checkout because they change.
The Advanced and Ultimate bundles are the full system, serum plus capsules. The single-serum Starter has a small shipping charge added.
Synevra is sold online only, which means marketplace listings for it are either resellers or copies. Neither is covered by the refund and you can't tell how old the bottle is. The official store takes payment through BuyGoods, so the charge on your card will say BuyGoods rather than Synevra; that's normal, not a sign something's wrong. Details on the where to buy page.

Sixty days from purchase. If you're not happy, contact customer service and ask for a refund. The brand describes it as no-questions-asked.
Keep the order email. You may be asked to send the bottles back, so hang on to them. It's a one-off purchase with no subscription, and the refund only applies to orders from the official site.
| Feature | Synevra UltraLift | Regular Anti-Aging Creams |
|---|---|---|
| Main Purpose | Firmness, hydration & youthful-appearance support | Surface-level moisture & skincare |
| Use Type | Serum + optional nutrient capsule (dual-action) | Topical cream only |
| Focus | Elasticity, texture & visible aging signs | Moisture & surface appearance |
| Best For | Adults wanting daily inside-and-out support | Basic skincare users |
| Replaces Dermatology Care? | No | No |
A peptide serum for the look of firmer, smoother, better-hydrated skin, sold on its own or bundled with the VitaLock nutrient capsule as the Lift & Lock System. Main actives: SYN-AKE peptide, sodium hyaluronate, vitamins C and E, glycerin. It's a cosmetic, not a treatment.
The serum works on the surface: the peptide softens the look of expression lines, hyaluronic acid pulls water into the skin so it looks plumper, and vitamins C and E brighten and protect. The optional capsule supplies biotin, niacinamide, B6, zinc and horsetail from the inside. Hydration shows quickly; the rest takes weeks.
The serum: Dipeptide Diaminobutyroyl Benzylamide Diacetate (SYN-AKE), sodium hyaluronate, ascorbic acid (vitamin C), tocopheryl acetate (vitamin E) and glycerin. The VitaLock capsule: biotin, niacinamide, vitamin B6, zinc and horsetail extract. Concentrations aren't published.
It's made for the look of fine lines, particularly expression lines. SYN-AKE has cosmetic studies showing softer-looking forehead and eye lines over about a month, and hyaluronic acid makes lines look shallower by plumping the skin. It won't remove deep, set-in wrinkles.
Hydration effects, dewier and softer-looking skin, often show within days. The peptide and antioxidant effects on the look of lines and tone take four to eight weeks of daily use. The 60-day refund covers that window.
For most adults, yes. It's non-GMO, paraben-free and cruelty-free, and the ingredients are standard skincare actives. The usual cautions apply: patch-test first, don't use on broken or irritated skin, and check with a dermatologist if you have sensitive skin, allergies, or use prescription skincare.
Occasionally mild redness, tingling or dryness, mostly in people with sensitive skin or an allergy to a listed ingredient. Patch-testing on the jawline for a few days catches most of that before it reaches your face.
Under-18s, women who are pregnant or nursing, anyone with a known allergy to a listed ingredient, anyone on prescription skincare without their prescriber's okay, anyone with active irritation or broken skin, and anyone whose dermatologist has told them to hold off on new products.
Only from the official website, where checkout runs through BuyGoods. It isn't in shops or on marketplaces; any listing there is a reseller or a copy with no refund attached.
No. It's a cosmetic that improves how skin looks. It doesn't replace a dermatologist, prescription treatments, or procedures, and it won't treat a skin condition.
Yes, 60 days from purchase, described by the brand as no-questions-asked. Contact customer service, keep your order email, and be ready to return the bottles if asked. Official-site orders only.
Lee YI, et al. (2019) "Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression." Int J Mol Sci. PMID: 31861912
Draelos ZD, et al. (2022) "Multicenter evaluation of a topical hyaluronic acid serum." J Drugs Dermatol. PMID: 35833366
Jegasothy SM, et al. (2014) "Efficacy of a New Topical Nano-hyaluronic Acid in Humans." J Clin Aesthet Dermatol. PMID: 24688623
Salwowska N, et al. (2019) "Topical Hyaluronic Acid Facial Cream with New Micronized Molecule Technology." J Clin Aesthet Dermatol. PMID: 32038748
Nusgens BV, et al. (2001) "Topically applied vitamin C enhances the mRNA level of collagens I and III in the human dermis." J Invest Dermatol. PMID: 11407971
Al-Niaimi F, Chiang NYZ (2017) "Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications." J Clin Aesthet Dermatol. PMID: 29104718
Fitzpatrick RE, Rostan EF (2002) "Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage." Dermatol Surg. PMID: 11896774
Sanadi RM, Deshmukh RS (2023) "Efficacy of topical vitamin C in melasma and photoaging: A systematic review." J Cosmet Dermatol. PMID: 37128827
Kawada A, et al. (2008) "Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide." J Dermatol. PMID: 19017042
Chiu PC, et al. (2007) "Clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled trial." J Cosmet Dermatol. PMID: 18047609
Thompson KG, Kim N (2020) "Dietary supplements in dermatology: zinc, biotin, vitamin D, nicotinamide, and Polypodium." J Am Acad Dermatol. PMID: 32360756
Dhaliwal S, et al. (2020) "Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review." Am J Clin Dermatol. PMID: 31745908
These studies are about the individual ingredients, often at concentrations and in formulations that may differ from Synevra's, which hasn't been tested as a finished product. Synevra UltraLift is a cosmetic, not a medicine, and nothing here is a treatment claim.
So, worth it? Our view: yes, for the right person. Synevra tells you what's in it, the ingredients are the ones dermatology research keeps coming back to, the wording on the box is careful rather than hysterical, and the bundle pricing is fair. The 60-day refund means the cost of finding out whether your skin likes it is a bit of postage.
The caveat we'd want you to hear: this changes how skin looks, gradually, if you use it daily. It won't erase deep wrinkles and it isn't a replacement for a dermatologist. It suits someone who wants a short, non-invasive routine and will give it six weeks. It doesn't suit someone with a diagnosed skin condition, someone with very reactive skin who won't patch-test, or someone hoping for injectable-level change from a pump bottle.
The Ultimate bundle at $59 a serum is the sensible buy: skincare only works if you keep using it, the per-bottle price is lowest, shipping is free, and you get enough to give it a real trial.
And whichever you pick, patch-test first, and talk to a dermatologist before starting if you have sensitive skin, allergies, are pregnant or nursing, or use prescription skincare. A serum is a small thing to be cautious about, and it's still worth being cautious.
A peptide serum and a nutrient capsule, non-GMO and cruelty-free, with 60 days to change your mind.
Order from the Official WebsiteFrom $59/serum on the bundle · FREE shipping · 2 free eBooks · 60-day guarantee